Contrary to popular belief, the frequency of prostatitis identified and confirmed by laboratory tests is only about 9%.However, prostate glands often repeats or becomes chronic.
The prevalence of chronic forms of prostatitis, characterized by an inactive inflammatory process and smaller clinical symptoms that reduce the quality of life, is difficult to assess.
In addition to acute and chronic bacterial prostatitis, the chronic inflammatory syndrome of the pelvic pelvic, in which leukocytes are discovered in the third part of the urine or seminal fluid, as well as chronic syndrome pain pelvis without inflammatory changes.
In the occurrence and maintenance of symptoms characteristic of chronic prostatitis, expressed in high urination pressure, intraprostatic reflux that forms turbulent urine, immune reactions and modified pelvic muscle condition, are of great importance.
Periodic phenomenon and intensification of pain and symptoms of lower urinary tract (port), sleep disorders and often, erectile function significantly affects the physical and psychological state of man.
The most common symptoms of the lower urinary tract in young and middle years are caused by the inflammatory process in the prostate, however, given the patient's age, the differential diagnosis between Adenoma and prostate cancer is always needed.
There are different opinions regarding the pathogenesis of chronic prostatitis, based on which different treatment methods are proposed.The treatment of acute prostatitis depends on the identified pathogen and primarily include antibacterial medications that have the greatest penetration in the prostate tissue.
Acute bacterial prostatitis requires parenteral administration of bactericide antibiotics such as aminoglycosides or third-generation cephalosporine.Treatment continues until the fever disappears and the blood is normalized.Fluoroquinoloni can be prescribed in less difficult cases.The duration of fluoroquinolons for acute prostatitis is 2-4 weeks.
For chronic bacterial prostatitis and inflammatory syndrome of chronic pelvic pain, treatment is performed with fluoroquinolones or trimetoprim.The patient is then re-examined, and antibiotics continue only in cases where the microorganism that caused a disease known or if the patient noticed a positive effect from therapy.
The recommended treatment period for chronic prostatitis is 4-6 weeks or more.Urodynamic studies have shown an increased urethral pressure.In this regard, it was observed that the combined treatment of blockers and antibiotics is more efficient than antibiotic monotherapy in the inflammatory syndrome of chronic pulp pain.When it comes to the course of therapy, the doctor should talk to the patient with his duration, the probability of side effects, as well as the need to monitor the efficiency and safety of treatment.
Herbal remedies in the treatment of chronic prostatitis
The use of plant preparations in the treatment of the prostate disease has a long history.Evidence of the efficiency and safety of plant medicine are obtained empirically.
Currently, the possibility of using plant remedies should be determined by modern ideas on pathogenesis and the development of pathological processes, especially in prostate.
Processes such as functional obstruction, turbulence in the prostatura urethra, pathological impact of combined microorganisms, immune changes, disrupt normal metabolism.Some violations inevitably lead to others.For example, chronic inflammation leads to cellular disorders and damage.
Usually, the body constantly produces incomplete oxidation products, so-called free radicals, of which the number increases in different pathological conditions, especially during inflammation.The disorder in the supply oxygen on tissues, in which the accumulation rate of active radical compounds (oxygen, nitrogen and chlorine radicals) exceeds the speed of their neutralization, is called oxidative stress.As a result, oxidative stress leads to tissue damage, including in prostate.
Biochemists have long known about natural antioxidants: vitamins e, c and carotenoids, but cannot seriously affect oxidative stress.In recent years, more and more attention is dedicated to bioflavonoids, which are tens of time stronger in antioxidants of vitamin E, vitamin C and beta-carotene.A total of more than 6,000 bioflavonoids are known, more than 3,000 flavons and more than 700 isoflavones.About 2% of the total organic carbon produced by photosynthesis are synthesized by plants in flavonoids or other polyphenols.
Flavonoids protect plants from radiation, ultraviolet irradiation, oxidation, disease, infection, bacteria.One of the representatives of medicinal plants containing bioflavonoids is the negliger Hedysarum, a perennial herbaceous plant from the legume family.This small plant, 25-50 cm high, blooms from June to August with small purple-purple flowers.
The roots of the forgotten Pennyed contain flavonoid quercetin, saponin and other biologically active substances.These are derivatives in Quercetin who have antioxidant activities and are effective in patients with chronic prostatitis, which confirm the results of clinical studies.
In addition to these properties, catechins contained in the root of forgotten Kopeck have high p-vitamin activity, strengthen capillary walls and optimize microcirculation.The roots of the forgotten Pennyed have adaptogenic properties that also determines the value of the plant involvement in complex patient therapy with chronic prostatitis.
They also contain flavonoids is Knotweed (polygonum of aviculare), annual herbaceous weed with small, elliptical leaves.One stem that extends from the base of root branches and produces mass of green shootings.This Matina growing plant has numerous inconspicuous greenish-white flowers in May.Knotweed also contains a large amount of ascorbic acid, vitamin K and provitamin A.
Products based on the plant quota have long been known in urological practice because they have diuretic, anti-gout and adaptogenic effect.Combined use of Commonweed and Knotweed allows us to expect a clinically significant effect.
Herbal remedies available in clinical practice, which are produced from commonweed (root and rhizomes), as well as the plant nodes, is the tincture of the root of forgotten common.
Biological active substances involved in tinctures contain natural antioxidants and substances that improve microcirculation, which determines the ability of these herbal remedies to reduce the severity of the inflammatory process (a sense of pain in the perineum, prostator).
Increased blood circulation in the prostate reduces the severity of smaller bladder symptoms (including frequencies, discharge of bladder, weakening the bladder discharge), and also improves the functional state of cavernous arteries.
Clinical tincture efficiency from the root of forgotten Kopeck
The efficiency of the tincture was studied in an open comparative randomized study.The purpose of the study was to study the effect of plant preparations on the dynamics of pain syndrome, objective data and laboratory parameters in patients with chronic prostatitis.
In addition to the study of complaints and medical histories, diagnosis confirmed the laboratory tests of prostate secretions in pure form or urine.In parallel groups with active control, the efficiency, safety and tolerability of medicinal in patients with chronic prostatitis was estimated.
In order to lens a description of the symptoms, the National Institute for Index of Hironical Prostatitis (NIH-CPSI), the analysis of urinary tract and laboratory data comparisons.In patients, urological diseases that could be accompanied by similar symptoms (benign hyperplasia, prostate cancer), pathological changes in the nervous system and gastrointestinal tract were excluded.
Debt streaming flow with periodic deterances negatively affects the emotional and sexual sphere.Observation and changes in erectile function against the background of chronic prostatitis in patients who have received the drug were also performed by standard questionnaires.In parallel, medicinal safety is estimated compared to other plant drugs.
In order to clarify the effective dose of the forgotten penny root tincture, patients were divided into two groups.The first group consisting of 30 people, received 1 teaspoon of tincture 3 times a day.Other group patients, which consisted of 30 people, took a tincture of 2 teaspoons 3 times a day.
The distribution of patients in the groups was performed using a simple randomization method, which enabled the study of the effects of the drug in homogeneous groups.The medicine red root plus is prescribed on an empty stomach, at least 30 minutes before eating.Before use, the drug bottle is shaken, and one dose is dissolved in 1/3 glass of water.The duration of treatment was 30 days.
The control group of 20 patients diagnoses chronic prostatitis received treatment with other plant preparation for the same period.Group efficiency criteria that used a tincture 1 tsp 3 times a day, 2 teaspoons 3 times a day or have taken a drug comparison in clinical symptoms based on clinical symptoms, based on patients, questionnaires and urination data.All included patients filled out the study.
The average age of patients in the first group, which has received a forgotten Kopecka root, 1 teaspoon (37-56) (as well as 25. and 75. Percentage ", as well as 25. and the percentage", as well as 25th.Group, which took the tincture of 2 teaspoons 3 times a day, was 45.5 (33-55) years. The average age of patients in the control group was 48 (36-59) years.
There were no statistically significant differences between groups between groups (p = 0.63) (below the analysis of variance).It should be noted that chronic prostatitis is identified in people of the most active and working age, for which the preservation of erectile and reproductive functions is especially important.Of all patients involved in the study, 26 (32.5%) had the history of sexually transmitted diseases.The distribution of such patients in groups was the same.
Before the prescribed tincture plus, 57 (71.3%) patients received treatment with chronic prostatitis.Most often, it was antibacterial therapy and / or α-blockers.Distribution of patients who previously received treatment, as well as the type of treatment, did not significantly differentiate between groups, which confirms modern ideas on pathogenesis and, accordingly, methods of treatment of chronic prostatitis.
In order to objectively assess the symptoms and their seriousness, as well as the quality of the patient's life, a NIH-CPSI scale was used for the basic assessment and to monitor patient status.Initially, the level of pain according to the NIH-CDE scale before treatment in the group that has received the penywort tincture of the Pennywort, 1 teaspoon 3 times a day, either 13 (10-15) points;In a group that has received the tincture of 2 teaspoons 3 times a day - 12 (10-15) points.In the control group, this indicator was 13 (10-15) points.The weight of pain between the groups did not have statistically significant differences (p = 0.846).
The patient groups were homogeneous both in the localization and severity of pain, which is especially important in view of the various clinical manifestations of this disease.
Since urinary disorders, namely the bladder obstruction, reinforced pressure in lumen reflux, play an important role among alleged causes and repetitions of chronic prostatitis, special attention is paid to the distribution of patients to the ground floor and discomfort.In the beginning, in the first group, this indicator was, according to the NAIH-CDE scale, 2 (1-3) points, in the second group - 2 (1-3) points and control - also 2 (1-3) points.
The weight of the urinary disorders did not differ significantly between the groups (p = 0.937).Study groups were homogeneous compared to dolls.There was no difference between groups in the results of the urination log analysis.It can be said with reasonable confidence that the arches are associated with the disease of prostate, and not functional bladder disorders or aquatic balance.
The maximum flow flow, according to uroflowetria, in the first group was 13.3 (11.8-14.2) ml / s, in the second group - 13.2 (12.1-14.0) ml / s, and in the control group - 13.0 (11.8-14.6) ml / s.There were no statistically significant differences in this indicator between groups (p = 0.9996).The amount of urine remaining in the first, second and control groups was 23.0 (20-26), 23 (18-25) and 20 (16,5-24) ml, respectively.The patient groups also did not differ in this indicator (p = 0.17).
It can be stated that the patients with chronic prostatitis shall not be detected in patients with chronic prostatitis in study groups, however, allow suspicions to doubt the source of pathological symptoms precisely at the Urethrh level.
The subjective perception of patients symptoms of chronic prostatitis is also of great importance.The diversity of unpleasant sensations of different severity, which are prone to repetition, often unpredictable, significantly disrupt the usual way of life of men.This does not only affect their mood, but also their social activity.Therefore, the quality of life is a study, which depends on the severity of the disease, its relapse and the consequences, also serves as a criterion for the effectiveness of treatment.
Before prescribed, in a group that has received the red root tincture plus 1 tsp 3 times a day, according to the questionnaire, in a group that has received 2 teaspoons 3 times a day - in the control group - in 6 (3-9) points.There were no statistically significant differences between groups for this indicator (P = 0.22).
The total score on the NIH-CPSI scale in the first group was 22 (19-25), in the second group - 23 (19-25), and in control - 22 (18-25) (p = 0.801).Therefore, groups were homogeneous not only in terms of the sum of results on the chronic scale of prostatitis symptoms, but also in terms of its individual components.All patients answered questions about the male copulative scale of copulatives (MCF).In the first group, the indicator was 31 (23-41) points, in the second - 34 (27-39) points, in the third - 34 (26-37) points.The effect of chronic prostatitis on the erectile function remains the subject of the study.
In all three groups, the range of values is quite wide.This indicates an individual degree of man's response to his symptoms and disorders.However, the distribution of patients with chronic prostatitis with different stations of erectile function in groups before treatments do not differ (p = 0.967).Thus, at the beginning of the study, it was possible to form three groups of patients with chronic prostatitis, which were homogeneous in the age, type and severity of clinical symptoms, which influenced the quality of life.At the same time, the tank exchanges and the evacuation of the bladder bladder were excluded.
After 30 days of treatment, symptoms were rated in formed groups.In the group of patients who have received a forgotten pennyeed root tincture, 1 teaspoon 3 times a day, according to the control questionnaire, the reduction in frequency and severity of pain and discomfort remarked 51%.When taking tincture 2 teaspoons 3 times a day, a reduction in the severity of symptoms for 55% was recorded.
In the control group pathological symptoms were reduced by 37%.The differences between the three groups of patients were statistically significant (p = 0.029).However, between the first and other groups, no statistically significant differences were found.Therefore, it is possible to achieve a clinically significant effect with minimal doses of the drug.In addition, statistically significant differences have remained in reducing pathological symptoms when evaluating each group that took a forgotten Kopeck's root tincture, compared to control.
According to the questionnaire, there was an improvement of urinary effect in patients with chronic prostatitis during treatment, but differences were not statistically significant or between groups that received the penywort tincture in different doses, and in relation to the control group.
During the analysis of data on the wet diary, the statistically significant differences in all three groups were not and statistically significant differences.According to Uroflowetri, the results of the Uroflowetriytriy control, an increase in the maximum urinary flow rate in all groups, which ranged from 5 to 12%.The scope of the remaining urine in patients receiving medicine in different doses, and in patients receiving treatment with plant reference medicine, decreased by 4-6%.The differences between the groups were not statistically significant.
This fact can be explained by a relatively short period of use, as well as the absence of components in the red root plus tincture that would have an effect similar to α-adrenergic blockers and 5α-reductase inhibitors.The main active ingredient of the drug is compounds from the bioflavonoid group, which have different effects, primarily antioxidants and anti-inflammatory effects.
According to the control examination, based on repeated examination, improving the quality of life indicators was recorded after treatment for 30 days.In the first group, this figure has changed by 55%, in the other - for 59%, and in the control group - by 39%.Differences in the dynamics of changes in quality of life during the use of the forgotten Kopeck's root tincture and in the control group were statistically significant (p = 0.008).
It should be noted that the groups that received tinctuus in different doses do not differ significantly in the dynamics of quality of life.Analysis of changes in quality of life confirms adaptogenic effect of plant preparation components that contains forgotten Kopek and Knotweed.The total result of NIH-CPSI decreased into all three groups after 30 days of treatment.In the first group, there was a decrease of 50%, in the second - for 52%, and in the third - by 29%.At the same time, the same trend was observed as in the analysis of other indicators.
The difference was statistically significant between patients who received the tincture of the root of forgotten kopeck and patients in the control group, and between groups that were not found differences in different docks.
All three groups of patients have shown the same increase in the total result on the ICF questionnaire (p = 0.455).Changing indicators in all groups was no more than 10%.There were no statistically significant differences between groups.
Improving the cessation function can be connected primarily by reducing pathological simptoms of prostate, decrease in luh, adaptogenic properties and improved microcirculation.The state of the prostate during the use of plant preparations is interesting.This is shown by analyzing the results of the repeated prostate excretion study.
If the patients did not differ in the presence and number of leukocytes in the excretion of the prostate (P = 0,528), then after 30 days of treatment in all groups there was a reduction in the severity of the inflammatory process.In groups that received the forgotten pennyeed root tincture, a statistically significant (p = 0.028) decline in leukocytes in relation to the control group.Changing the dosing of the drug did not affect the dynamics of leukocytes.
According to the survey of the Secret Prostate, a significant reduction in the seriousness of the inflammatory process and improvement of the functional states of the prostate gland has been established.
Different herbal remedies contain an individual set of bioflavonoids that have different activities.Obviously, a combination of rhizomes and roots of common and nodes contains bioflavonoids that are active against the effects of oxidative stress in prostate tissue.This can be assumed based on the results of the efficiency of the drug and the lack of a dose dependent difference.However, this assumption must be confirmed by further research.
Conclusion
Among the methods of prostatitis treatment, the use of plant preparations occupies a significant place.The efficiency of this group of drugs is confirmed by clinical experience.However, the implementation of randomized clinical trials aimed at assessing the efficiency of plant preparations based on modern ideas about the active principle allows us to take over new access to plant medicine.
The effectiveness of herbal bioflavonoids is justified by the theory of oxidative stress, according to which the products are uncontrolled radical oxidations harmful impact on cell and cause many bodies and system dysfunction.
Taking into account the above, plant medicine seems to be a forgotten kopeck's root tincture, a healing product with anti-inflammatory and antioxidant effects, in a complex treatment of patients with chronic prostatitis and monotherapy for the prevention of this disease.